The main focus in this thesis is the analysis of alternative approaches for estimation and control of automotive vehicles based on sound theoretical principles. Of particular importance is the problem rollover prevention, which is an important problem plaguing vehicles with a high center of gravity (CG). Vehicle rollover is, statistically, the most dangerous accident type, and it is difficult to prevent it due to the time varying nature of the problem. Therefore, a major objective of the thesis is to develop the necessary theoretical and practical tools for the estimation and control of rollover based on robust and adaptive techniques that are stable with respect to parameter variations. Given this background, we first consider an implementation of the multiple model switching and tuning (MMST) algorithm for estimating the unknown parameters of automotive vehicles relevant to the roll and the lateral dynamics including the position of CG. This results in high performance estimation of the CG as well as other time varying parameters, which can be used in tuning of the active safety controllers in real time. We then look into automotive rollover prevention control based on a robust stable control design methodology. As part of this we introduce a dynamic version of the load transfer ratio (LTR) as a rollover detection criterion and then design robust controllers that take into account uncertainty in the CG position. As the next step we refine the controllers by integrating them with the multiple model switched CG position estimation algorithm. This results in adaptive controllers with higher performance than the robust counterparts. In the second half of the thesis we analyze extensions of certain theoretical results with important implications for switched systems. First we obtain a non-Lyapunov stability result for a certain class of linear discrete time switched systems. Based on this result, we suggest switched controller synthesis procedures for two roll dynamics enhancement control applications. One control design approach is related to modifying the dynamical response characteristics of the automotive vehicle while guaranteeing the switching stability under parametric variations. The other control synthesis method aims to obtain transient free reference tracking of vehicle roll dynamics subject to parametric switching. In a later discussion, we consider a particular decentralized control design procedure based on vector Lyapunov functions for simultaneous, and structurally robust model reference tracking of both the lateral and the roll dynamics of automotive vehicles. We show that this controller design approach guarantees the closed loop stability subject to certain types of structural uncertainty. Finally, assuming a purely theoretical pitch, and motivated by the problems considered during the course of the thesis, we give new stability results on common Lyapunov solution (CLS) existence for two classes of switching linear systems; one is concerned with switching pair of systems in companion form and with interval uncertainty, and the other is concerned with switching pair of companion matrices with general inertia. For both problems we give easily verifiable spectral conditions that are sufficient for the CLS existence. For proving the second result we also obtain a certain generalization of the classical Kalman-Yacubovic-Popov lemma for matrices with general inertia.