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Bayram, Ozgur, Krappmann, Sven, Ni, Min, Woo Bok, Jin, Helmstaedt, Kerstin, Valerius, Oliver, Braus-Stromeyer, Susanna A., Kwon, Nak-Jung, Keller, Nancy, Yu, Jae-Hyuk and Braus, Gerhard H. (2008) VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism. Science, 320 (5882). pp. 1504-1506. ISSN 0036-8075
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Abstract
Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In
Aspergillus nidulans
, light inhibits sexual reproduction as well as secondary metabolism. We identified
the heterotrimeric
velvet
complex VelB/VeA/LaeA connecting light-responding developmental
regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark,
physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the
nuclear master regulator of secondary metabolism, LaeA. Deletion of either
velB
or
veA
results in
defects in both sexual fruiting-body formation and the production of secondary metabolites.
| Item Type: | Article |
|---|---|
| Keywords: | VelB/VeA/LaeA; Complex Coordinates; Light Signal; Fungal Development; Secondary Metabolism; |
| Academic Unit: | Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Hamilton Institute |
| Item ID: | 8159 |
| Identification Number: | 10.1126/science.1155888 |
| Depositing User: | Ozgur Bayram |
| Date Deposited: | 12 Apr 2017 15:27 |
| Journal or Publication Title: | Science |
| Publisher: | American Association for the Advancement of Science |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mu.eprints-hosting.org/id/eprint/8159 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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