A new embedded telemetry system for amperometric biosensor application is presented. The device consists of a single-supply miniature potentiostat-I/V converter, a microcontroller unit (MCU), a signal transmitter, and a stabilized power supply. The sensor current is converted to a digital value using a peripheral interface controller (PIC) MCU with an integrated analog-to-digital converter (ADC). The PIC firmware is developed in assembly and transferred to the MCU through an in-circuit-serial-programmer (ICSP). The digital data are sent to a personal computer using a miniaturized 433.92 MHz amplitude modulation (AM) transmitter with a linear range up to 30 m. The radio receiver is connected to a PC via a Universal Serial Bus (USB). Custom developed software, written in C and Basic, allows the PC to record, plot and handle the received data. The design, construction and operation of the hardware and software are described. The system performance was evaluated in vitro using a dummy cell and a platinum (Pt) amperometric glucose biosensor. This device serves as a basic model to realize an in vivo, low-cost, miniaturized telemetry system built with standard hardware components readily available.