Geographically weighted regression (GWR) is an important local technique for exploring spatial heterogeneity in data relationships. In fitting with Tobler’s first law of geography, each local regression of GWR is estimated with data whose influence decays with distance, distances that are commonly defined as straight line or Euclidean. However, the complexity of our real world ensures that the scope of possible distance metrics is far larger than the traditional Euclidean choice. Thus in this article, the GWR model is investigated by applying it with alternative, non- Euclidean distance (non-ED) metrics. Here we use as a case study, a London house price data set coupled with hedonic independent variables, where GWR models are calibrated with Euclidean distance (ED), road network distance and travel time metrics. The results indicate that GWR calibrated with a non-Euclidean metric can not only improve model fit, but also provide additional and useful insights into the nature of varying relationships within the house price data set.