Ecofeminism (Silvey 1998) and Queer Ecology (Gandy 2012) highlight relations among gender, sexuality, and nature. The agenda of ‘queering ecology[, …] opening up […] environmental understanding to explicitly non-heterosexual forms of relationship, experience, and imagination as a way of transforming entrenched sexual and natural practices towards […] queer […] ends’ (Mortimer-Sandilands and Erickson 2010, 30), resonates within Medical Geography and Epidemiology. This essay shows how we might track the effects of entrenched homophobia within the geographical framing of disease by examining one important set of epidemiological writings, those in which AIDS was first registered as a new mortality. I show how homophobic stereotypes shaped scientific writings, and how, in related but different ways, they pervaded the public geographies of AIDS circulating in the mass media. Finally, I will show how activists tried to undo the murderous homophobia of AIDS discourses building understandings of HIV vulnerability that were accepting of sexual diversity, effectively queering epidemiology.