Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase

Share and Export

Singh, Ishwar and Heaney, Frances (2010) Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase. Organic & Biomolecular Chemistry, 8 (3). pp. 451-456. ISSN 1477-0520

PDF
FH_metal_free.pdf
Download (145kB)

Abstract

A fast and practical metal free conjugation of ribonucleosides and 2¢-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3¢- or the 5¢-terminus of the oligoribonucleotide substrate.

Item Type:	Article
Keywords:	Metal free; “click and click–click” conjugation; ribonucleosides; 2′-OMe oligoribonucleotides;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	4293
Depositing User:	Dr. Frances Heaney
Date Deposited:	09 Apr 2013 10:37
Journal or Publication Title:	Organic & Biomolecular Chemistry
Publisher:	Royal Society of Chemistry
Refereed:	Yes
Related URLs:	Publisher
URI:	https://mu.eprints-hosting.org/id/eprint/4293
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

MURAL - Maynooth University Research Archive Library

Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase

Abstract

Repository Staff Only (login required)

Downloads

Origin of downloads