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Freeman, Colin, Ni Cheallaigh, Aisling and Heaney, Frances (2011) Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry. Tetrahedron, 67 (40). pp. 7860-7865. ISSN 0040-4020
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Abstract
The versatility of the isoxazole generating nitrile oxide–alkyne Huisgen cycloaddition for provision of chemically modified oligonucleotides has been extended; in a novel approach isoxazole conjugated oligodeoxyribonucleotides have been constructed by phosphoramidite chemistry of isoxazole derivatives previously generated by nitrile oxide–alkyne click chemistry. The conjugation involves manual solid phase synthesis at room temperature in aqueous ethanol and proceeds in high yield.
| Item Type: | Article |
|---|---|
| Keywords: | Conjugation; oligonucleotide; isoxazole phosphoramidites; click chemistry; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 4292 |
| Depositing User: | Dr. Frances Heaney |
| Date Deposited: | 09 Apr 2013 10:07 |
| Journal or Publication Title: | Tetrahedron |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mu.eprints-hosting.org/id/eprint/4292 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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