Objective: This study investigated the prevalence of symptoms of depression and anxiety in a sample of predominantly elderly males with acquired upper limb amputations (n = 138) and examined the contribution of coping strategies to the prediction of psychosocial adjustment. Method: One-hundred and thirty-eight men with injury-related upper limb amputations completed self-report questionnaires assessing coping strategies, symptoms of anxiety and depression, and psychosocial adaptation to prosthesis use. Results: Prevalence of significant depressive symptoms was 28.3% (HADS-D score ≥8). Prevalence of significant anxiety symptoms was 35.5% (HADS-A score ≥8). Coping styles emerged as important predictors of psychosocial adaptation. In particular, avoidance was strongly associated with psychological distress and poor adjustment. Conclusions: These findings suggest the potential benefits of interventions to reduce reliance on avoidant coping and stimulate more problem-focused approaches to coping with difficulties and challenges in order to facilitate adaptation and prevent problems in psychosocial functioning post-amputation.