In this article I propose an interpretation of the recent Colombian cinema from a perspective that combines Queer Theory with Disability Studies. For this, I take as a case study the film Porfirio (2011) by Alejandro Landes. The analysis focuses on three areas: firstly, I discuss recent Colombian cinema and establish the importance of addressing the construction of (physical) disability in that cultural industry. Subsequently, I examine the way in which sexuality, the body and disability are articulated in Landes’ film through an analysis of their visual grammar. Finally, I establish the (sociopolitical) contributions that this film generates in the current Colombian context when a queer/ crip affective approach is assumed. In this way, this paper seeks to promote more extensive research on the representation of (physical) disability in Colombian cinema created in recent decades and, in particular, how it produces affects and effects in Colombian conflictive society.