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Calatrava‐Pérez, Elena, Marchetti, Luke A., McManus, Gavin J., Lynch, Dylan M., Elmes, Robert B. P., Williams, D. Clive, Gunnlaugsson, Thorfinnur and Scanlan, Eoin M. (2022) Real‐Time Multi‐Photon Tracking and Bioimaging of Glycosylated Theranostic Prodrugs upon Specific Enzyme Triggered Release. Chemistry – A European Journal, 28 (3). ISSN 0947-6539
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Abstract
Real-timetracking of pro drug up take, delivery and activation in vivore presents a major challenge for prodrug development. Here in, we demonstrate the use of novel glycosylated theranostics of the cancer pharmacophore Amonafide in highly-selective, enzymatic triggered release. We show that the use of endogenous enzymes for activated release of the therapeutic component can be observed, in real time, and monitored using one and two-photon bioimag-ing, offering unique insight into the prodrug pharmaco kinetic profile. Furthermore, we demonstrate that the potent cytotoxicity of Amonafide is preserved using this targeted approach.
| Item Type: | Article |
|---|---|
| Additional Information: | Cite as: E. Calatrava-Pérez, L. A. Marchetti, G. J. McManus, D. M. Lynch, R. B. P. Elmes, D. C. Williams, T. Gunnlaugsson, E. M. Scanlan, Chem. Eur. J. 2022, 28, e202103858 |
| Keywords: | Prodrug; Amonafide; endogenous enzymes |
| Academic Unit: | Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute |
| Item ID: | 17385 |
| Identification Number: | 10.1002/chem.202103858 |
| Depositing User: | Robert Elmes |
| Date Deposited: | 06 Jul 2023 14:04 |
| Journal or Publication Title: | Chemistry – A European Journal |
| Publisher: | Wiley |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mu.eprints-hosting.org/id/eprint/17385 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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