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Wu, Luling, Gardiner, Jordan E., Kumawat, Lokesh Kumar, Han, Hai-Hao, Guo, Ruiying, Li, Xin, He, Xiao-Peng, Elmes, Robert B.P., Sedgwick, Adam C., Bull, Steven D and James, Tony D. (2019) Coumarin-based fluorescent ‘AND’ logic gate probes for the detection of homocysteine and a chosen biological analyte. RSC Advances, 9. pp. 26425-26428. ISSN 2046-2069
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Abstract
With this research we set out to develop a number of coumarin-based ‘AND’ logic fluorescence probes that
were capable of detecting a chosen analyte in the presence of HCys. Probe JEG-CAB was constructed by
attaching the ONOO� reactive unit, benzyl boronate ester, to a HCys/Cys reactive fluorescent probe, CAH.
Similarly, the core unit CAH was functionalised with the nitroreductase (NTR) reactive p-nitrobenzyl unit to
produce probe JEG-CAN. Both, JEG-CAB and JEG-CAN exhibited a significant fluorescence increase when
exposed to either HCys and ONOO� (JEG-CAB) or HCys and NTR (JEG-CAN) thus demonstrating their
effectiveness to function as AND logic gates for HCys and a chosen analyte.
| Item Type: | Article |
|---|---|
| Keywords: | Coumarin-based fluorescent; logic gate; probes; detection; homocysteine; chosen; biological analyte; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 13853 |
| Identification Number: | 10.1039/C9RA04908H |
| Depositing User: | Robert Elmes |
| Date Deposited: | 22 Jan 2021 11:10 |
| Journal or Publication Title: | RSC Advances |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mu.eprints-hosting.org/id/eprint/13853 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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