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Kelada, Mark, Walsh, John M.D., Devine, Robert, McArdle, Patrick and Stephens, John C. (2018) Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation. Beilstein Journal of Organic Chemistry, 14. pp. 1222-1228. ISSN 1860-5397
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Abstract
A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.
| Item Type: | Article |
|---|---|
| Additional Information: | This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite as: Kelada, M.; Walsh, J. M. D.; Devine, R. W.; McArdle, P.; Stephens, J. C. Beilstein J. Org. Chem. 2018, 14, 1222–1228. doi:10.3762/bjoc.14.104 |
| Keywords: | microwave-assisted synthesis; nitrogen-fused heterocycle; one-pot; pyrimidinone; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 10745 |
| Identification Number: | 10.3762/bjoc.14.104 |
| Depositing User: | Dr John Stephens |
| Date Deposited: | 24 Apr 2019 13:59 |
| Journal or Publication Title: | Beilstein Journal of Organic Chemistry |
| Publisher: | Beilstein-Institut |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mu.eprints-hosting.org/id/eprint/10745 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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